CD70 antibody

Catalog No. ABIN2567914

This anti-CD70 antibody is a Rat Monoclonal antibody detecting CD70 in FACS and Func. Suitable for Mouse.

Quick Overview for CD70 antibody (ABIN2567914)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: FR70

Product Details anti-CD70 Antibody

Specificity: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.

Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C. Do not freeze.

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.

Gene ID: 21948

UniProt: O55237

Pathways: Cancer Immune Checkpoints